← PROTOCOLS
🧐 Altered Mental Status
AEIOU-TIPS • Glucose • AVPU
2
Initial Assessment — ABCs + C-Spine
  • Airway: Maintain — jaw thrust, OPA/NPA if not responsive. Suction if needed (vomit, blood).
  • Breathing: Rate, depth, effort. Agonal or absent → BVM immediately.
  • Circulation: Pulse quality, skin signs, BP.
  • C-spine: If trauma mechanism present (fall, MVA, unknown) — manual inline stabilization until cleared.
  • Position: Recovery position if breathing and no C-spine concern.

📊 Step 3 — AVPU Scale

A
Alert
Awake, aware, responds normally
V
Verbal
Responds to verbal stimuli only
P
Pain
Responds to painful stimuli only
U
Unresponsive
No response to any stimulus
📉

STEP 4 — GLUCOSE CHECK: IMMEDIATE PRIORITY

BGL < 60 mg/dL → Treat before continuing. Hypoglycemia is the most reversible and dangerous AMS cause. Do not skip this step.

Hypoglycemia Treatment

🧩 Step 5 — AEIOU-TIPS Differential

Tap any category to expand. Check applicable causes to prioritize differential.
A
Alcohol / Drugs
Intoxication, withdrawal, CNS depressants
Alcohol breath, pinpoint pupils (opioids), dilated pupils (stimulants), drug paraphernalia. Check: ETOH level, Narcan trial for opioid OD (ALS or authorized BLS). Alcohol withdrawal: seizures, delirium tremens — high risk.
E
Epilepsy / Endocrine
Seizure, postictal, thyroid storm, Addisonian
Post-seizure: Todd's paralysis (focal weakness), incontinence, tongue biting, postictal confusion (minutes to hours). Thyroid storm: fever, tachycardia, diaphoresis, AMS. Addisonian crisis: hypotension, weakness, electrolyte derangement.
I
Insulin (Glucose)
Hypoglycemia, DKA, HHNS
Hypoglycemia: <60 mg/dL — diaphoresis, tremor, confusion, seizure. DKA: fruity breath, Kussmaul breathing, dehydration, BGL >250. HHNS (Type 2): extreme hyperglycemia, no fruity breath, profound dehydration.
O
Overdose / Oxygen
Drug OD, hypoxia, CO poisoning
Opioid OD: pinpoint pupils, respiratory depression, bradycardia. Hypoxia: cyanosis, SpO2 low, work of breathing. CO poisoning: cherry red skin, headache, nausea — SpO2 falsely normal (use CO-oximeter or clinical suspicion). High-flow O2 for CO.
U
Uremia
Renal failure, electrolyte disorders
Uremia from acute or chronic renal failure. Uremic frost (white crystals on skin — severe). Electrolyte derangements: hyponatremia (seizures), hyperkalemia (cardiac arrhythmias). Dialysis patient who missed treatment.
T
Trauma
Head injury, intracranial bleed
TBI: contusion, epidural/subdural hematoma. Signs: lucid interval then deterioration (epidural), Battle's sign (mastoid bruising), raccoon eyes, CSF rhinorrhea/otorrhea. C-spine protection. Rapid transport to trauma center.
I
Infection
Sepsis, meningitis, encephalitis
Sepsis: fever/hypothermia, tachycardia, hypotension, altered LOC, infection source. Meningitis: fever + severe headache + neck stiffness (meningismus) + photophobia — use droplet PPE. Encephalitis: fever + AMS + seizures.
P
Psychiatric / Poisoning
Psych emergency, toxins, medications
Psych emergency: diagnosis of exclusion. Always rule out organic cause first. Toxicology: toxic syndromes (cholinergic — SLUDGE, anticholinergic — dry/flushed/tachycardia, sympathomimetic). Document all medications found.
S
Stroke / Shock / Structural
CVA, hemorrhagic shock, mass lesion
Stroke: focal deficits, Cincinnati positive → Stroke Alert protocol. Shock: any type (distributive, hypovolemic, cardiogenic, obstructive) → hypoperfusion → AMS. Brain tumor/mass: focal deficits, headache, papilledema.
📋 Priority Differentials Based on Selection
Check applicable AEIOU-TIPS categories above to see prioritized differential

🔍 Step 6 — Physical Findings Panel

👁 Pupils
Pinpoint → opioid OD
Dilated → stimulants/anoxia
Unequal (anisocoria) → herniation
Fixed & dilated → severe brain injury
🦾 Motor
Focal weakness → stroke/TBI
Decorticate posturing → cortical
Decerebrate posturing → brainstem
Flaccid → severe injury
🦴 Meningismus
Neck stiffness
Kernig's sign
Brudzinski's sign
→ Meningitis / SAH
🩷 Skin
Diaphoresis → shock/hypoglycemia
Flushed/dry → anticholinergic
Petechiae/purpura → meningococcemia
Cherry red → CO poisoning

🩺 Step 7 — Management by Etiology

General AMS Management
🛡️
BLS Airway protection first — position, jaw thrust, OPA/NPA. Suction. Recovery position if spontaneous breathing.
💨
BLS O2 — apply per SpO2. 100% NRB if suspected CO poisoning (do not wait for O2 sat).
📉
BLS Glucose: BGL < 60 + conscious → oral glucose gel. Document pre- and post-treatment BGL.
🩸
ALS IV access, D50/D10 for hypoglycemia, Narcan 0.4-2mg IV/IM/IN for suspected opioid OD (respiratory depression + pinpoint pupils).
🌡️
BLS Temperature management: Hypothermia → warm blankets, remove wet clothing. Hyperthermia → cool with wet cloths, fan.
🚨 ALS Intercept Criteria
🔴 ALS Request — Any of the following:
  • AVPU below Alert — V, P, or U
  • BGL < 60 with unconscious patient (IV dextrose needed)
  • Suspected opioid overdose (Narcan)
  • Active seizure or postictal > 10 minutes
  • Signs of shock (hypotension, poor perfusion)
  • Suspected meningitis (droplet precautions)
  • Focal neurological deficits (stroke protocol)
  • Suspected CO poisoning (high-flow O2 only; hyperbaric consult)